Definition & Meaning | English word NELFINAVIR

Definitions of NELFINAVIR

1. (pharmaceutical drug) An antiretroviral drug (trademark Viracept) of the protease inhibitor class that is used in the form of its mesilate C₃₂H₄₅N₃O₄S·CH₄O₃S to treat HIV infected patients.

Examples of Using NELFINAVIR in a Sentence

• Nelfinavir belongs to the class of drugs known as protease inhibitors (PIs) and like other PIs is almost always used in combination with other antiretroviral drugs.
• Ranolazine should not be used with drugs such as ketoconazole, clarithromycin, and nelfinavir that strongly inhibit CYP3A, nor with drugs that activate CYP3A, such as rifampin and phenobarbital.
• There are ten HIV-1 PR inhibitors that are currently approved by the Food and Drug Administration: indinavir, saquinavir, ritonavir, nelfinavir, lopinavir, amprenavir, fosamprenevir, atazanavir, tipranavir, and darunavir.
• It is best to avoid strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin, and conivaptan.
• In the design process of nelfinavir, an orally bioavailable and nonpeptidic inhibitor, iterative protein cocrystal structure analysis of peptidic inhibitors was used and parts of the inhibitors were replaced by nonpeptidic substituents.
• 2, and 2,4,5-T, he was instrumental in significant developmental, reproductive, and/or nonclinical juvenile toxicity assessments of mirex, inorganic arsenic, nelfinavir (Viracept, an antiretroviral drug used to treat AIDS), fluoxetine (Prozac), two silicon-based ingredients found in breast implants and numerous personal care products (D4 and D5), methyl iodide, and HBOC-201 (a bovine hemoglobin-based oxygen carrier).

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