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- They are usually associated with multiple sclerosis or pertussis, but they may also be observed in other disorders such as encephalitis, head trauma, stroke, autism, asthma, trigeminal neuralgia, breath-holding spells, epilepsy, malaria, tabes dorsalis, and Behçet's disease, paroxysmal nocturnal hemoglobinuria (PNH).
- In 1912 he obtained his medical doctorate with a thesis on osteoarthropathy associated with tabes dorsalis.
- Tabes dorsalis is a late consequence of neurosyphilis, characterized by the slow degeneration (specifically, demyelination) of the neural tracts primarily in the dorsal root ganglia of the spinal cord (nerve root).
- His greatest contributions were made in the myopathies that came to immortalize his name, Duchenne muscular dystrophy, Duchenne-Aran spinal muscular atrophy, Duchenne-Erb paralysis, Duchenne's disease (Tabes dorsalis), and Duchenne's paralysis (progressive bulbar palsy).
- Noguchi discovered the presence of Treponema pallidum in the spinal cord of a patient with tabes dorsalis and paresis was due to late stage syphilis infection.
- Abadie's sign of tabes dorsalis is a medical sign of tabes dorsalis, a late consequence of neurosyphilis.
- He also published significant works on tabes dorsalis, alcoholism, anterior poliomyelitis, syphilis, multiple sclerosis and traumatic neurosis.
- Conditions affecting the dorsal columns of the spinal cord, such as tabes dorsalis (neurosyphilis), in which it was first described.
- Raymond made contributions in research of syringomyelia, neurasthenia, poliomyelitis, tabes dorsalis and diseases of the cauda equina, to name a few.
- Among his scientific publications was Der Augenbefund in seiner diagnostischen und differentialdiagnostischen Bedeutung bei Tabes dorsalis, Lues cerebrospinalis, Multipler Sklerose (1936), a neuro-ophthalmological analysis of eye disorders and their differential diagnostic relevance in tabes dorsalis, lues cerebrospinalis and multiple sclerosis.
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