Definition & Meaning | English word ACETYLCHOLINESTERASE

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Definitions of ACETYLCHOLINESTERASE

1. (enzyme) An enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid.

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Examples of Using ACETYLCHOLINESTERASE in a Sentence

• The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter.
• It is a potent inhibitor of acetylcholinesterase, a key enzyme within the human body as well as in other animals.
• The main type for that purpose is acetylcholinesterase (also called choline esterase I or plasma cholinesterase); it is found mainly in the blood plasma.
• It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.
• Anticholinergic drugs such as atropine can be used as an antidote for acetylcholinesterase inhibitor poisoning.
• she completed her DPhil degree in 1977 under the supervision of Anthony David Smith on the Origins of acetylcholinesterase in cerebrospinal fluid.
• Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents.
• Physostigmine, an acetylcholinesterase inhibitor, can be used to treat glaucoma and delayed gastric emptying.
• Tacrine is a centrally acting acetylcholinesterase inhibitor and indirect cholinergic agonist (parasympathomimetic).
• Esmolol is rapidly metabolized by hydrolysis of the ester linkage, chiefly by the esterases in the cytosol of red blood cells and not by plasma cholinesterases or red cell membrane acetylcholinesterase.
• Sarin is extremely poisonous because it attacks the nervous system by blocking the activity of cholinesterase enzymes present in it, including acetylcholinesterase.
• Memantine is used to treat moderate-to-severe Alzheimer's disease, especially for people who are intolerant of or have a contraindication to AChE (acetylcholinesterase) inhibitors.
• Oximes are drugs known for their ability to reverse the binding of organophosphorus compounds to the enzyme acetylcholinesterase (AChE).
• It is used as a clinical laboratory tool to distinguish between the cholinesterases; acetylcholinesterase and butyrylcholinesterase preferentially lyse acetylcholine and butyrylcholine, respectively.
• Bioactive secondary metabolites in clubmosses include triterpenoids with acetylcholinesterase inhibitor activity isolated from this species.
• lectins, streptavidin, monoclonal antibodies, phospholipase A2 and acetylcholinesterase, tailoring of bioreactive surfaces; mixed protein multilayers.
• Huperzine A is a naturally-occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata Huperzine A inhibits the breakdown of the neurotransmitter acetylcholine (ACh) by the enzyme acetylcholinesterase.
• Diisopropyl fluorophosphate is a parasympathomimetic drug irreversible anti-cholinesterase and has been used in ophthalmology as a miotic agent in treatment of chronic glaucoma, as a miotic in veterinary medicine, and as an experimental agent in neuroscience because of its acetylcholinesterase inhibitory properties and ability to induce delayed peripheral neuropathy.
• Sussman (born September 24, 1943) is an Israeli crystallographer best known for his studies on acetylcholinesterase, a key protein involved in transmission of nerve signals.
• Pralidoxime (2-pyridine aldoxime methyl chloride) or 2-PAM, usually as the chloride or iodide salts, belongs to a family of compounds called oximes that bind to organophosphate-inactivated acetylcholinesterase.
• Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication.
• Anticholinesterases are substances that interfere with the Central nervous system and the Peripheral nervous system by inhibiting acetylcholinesterase and therefore sustaining the effect of acetylcholine or butyrylcholine within the chemical synapses, resulting in a cholinergic crisis, and possibly death if untreated.
• Sugammadex, unlike neostigmine, does not inhibit acetylcholinesterase so cholinergic effects are not produced and co-administration of an antimuscarinic agent (glycopyrronium bromide or atropine) is not needed.
• The oxons then inhibit the acetylcholinesterase, causing acetylcholine to accumulate uncontrollably, wreaking havoc on the animal's nervous system.
• Like other organophosphates, dimethoate is an acetylcholinesterase inhibitor which disables cholinesterase, an enzyme essential for central nervous system function.

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