Definition & Meaning | English word AMYLOID-BETA

Definitions of AMYLOID-BETA

1. (biochemistry) Alternative form of amyloid beta.

Examples of Using AMYLOID-BETA in a Sentence

• Sequential cleavage by beta-secretase 1 (BACE) and gamma-secretase (γ-secretase) produces the amyloid-beta peptide fragment that aggregates into clumps called amyloid plaques in the brains affected by Alzheimer's disease.
• Helping to uncover the mystery behind protein aggregations—observed in Huntington's disease (inclusion bodies), Parkinson's disease (Lewy bodies), and Alzheimer's disease (neurofibrillary tangles and amyloid-beta plaques)—discovering that rather than being the culprit of neuronal death, these aggregates are part of a defense mechanism that safely sequesters toxin proteins in the brain.
• Some radioactive tracers used for Alzheimer's are florbetapir 18F, flutemetamol F18, PiB and florbetaben 18F, which are all used to detect amyloid-beta plaques (a potential biomarker for Alzheimer's) in the brain.
• "Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides", J Biol Chem 280, 37377–37382, 2005.
• Necrostatin-1, an anti-necroptotic molecule regulating both amyloid-beta misfolding and tau hyperphosphorylation.
• In January 2024, Rezai and a team at RNI published findings in The New England Journal of Medicine showing that opening of the blood-brain barrier using focused ultrasound increased removal of amyloid-beta (Aβ) plaques in Alzheimer’s disease patients undergoing anti amyloid-beta (Aβ) antibody treatment.
• Linse has demonstrated that the process of nucleation and growth of amyloid-beta peptide occurs in two phases; first the amyloid fibrils form and then monomers nucleate on the surface.

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