Definition & Meaning | English word CEFTRIAXONE

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Definitions of CEFTRIAXONE

1. (pharmaceutical drug) A synthetic cephalosporin antibiotic.

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Examples of Using CEFTRIAXONE in a Sentence

• In combination with doxycycline or azithromycin, ceftriaxone used to be recommended by the United States Centers for Disease Control and Prevention (CDC) for the treatment of uncomplicated gonorrhea.
• Historically, cefotaxime has been considered to be comparable to ceftriaxone (another third-generation cephalosporin) in safety and efficacy for the treatment of bacterial meningitis, lower respiratory tract infections, skin and soft tissue infections, genitourinary tract infections, and bloodstream infections, as well as prophylaxis for abdominal surgery.
• The result of the trial was that children treated with oral trovafloxacin had a 5% (5/100) mortality rate compared to a 6% (6/100) mortality rate with intramuscular ceftriaxone.
• To test its new antibiotic, trovafloxacin (Trovan), Pfizer gave 100 children trovafloxacin, while another 100 received the gold-standard anti-meningitis treatment, ceftriaxone, a cephalosporin antibiotic.
• In the US, neuroborreliosis is typically treated with intravenous antibiotics which cross the blood–brain barrier, such as penicillins, ceftriaxone, or cefotaxime.
• Antibiotics that Veillonella species are less resistant to or not resistant to at all include clindamycin, metronidazole, imipenem, ceftriaxone, and amoxicillin.
• The RAST system predicted genes encoding for functions such as cell wall metabolism, defense, carbohydrate metabolism, protein metabolism, RNA metabolism, lipid metabolism, and DNA metabolism Further annotation revealed potential functions involved in antibiotic resistance, but Resfinder demonstrated a higher sensitivity to antibiotics such as ceftriaxone and gentamicin.
• The cephalosporin series includes intermediate 7-ACA, cefazolin sodium, cefazolin acid and ceftriaxone sodium.
• Second choice: ceftriaxone (a third-generation cephalosporin) or cefepime (a fourth-generation cephalosporin) +/- amoxicillin or vancomycin.
• The following empirical treatment may be administered for a total of 6 weeks (PMID 26872859): - Ceftriaxone 2x2g and Clindamycin 3x600mg i.
• In a study comparing the safety and efficacy of levofloxacin to that of azithromycin or ceftriaxone in 712 children with community-acquired pneumonia, serious adverse events were experienced by 6% of those treated with levofloxacin and 4% of those treated with comparator antibiotics.
• These include: cefixime (an oral cephalosporin), ceftriaxone (an injectable cephalosporin), azithromycin, aminoglycosides, and tetracycline.
• FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.
• Such drugs include cefamandole, cefmenoxime, cefmetazole, cefonicid, cefoperazone, cefotetan, ceftriaxone, and latamoxef (moxalactam).
• Ceftriaxone is often considered for parenteral treatment, while oral or parenteral fluoroquinolones, such as levofloxacin and ciprofloxacin, are suitable alternatives for treating pyelonephritis.

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