Definition & Meaning | English word CLOBAZAM

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Definitions of CLOBAZAM

1. (organic compound, pharmaceutical drug) A benzodiazepine derivative used as an anxiolytic and anticonvulsant; C₁₆H₁₃ClN₂O₂.

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Examples of Using CLOBAZAM in a Sentence

• Clobazam, sold under the brand names Frisium, Onfi and others, is a benzodiazepine class medication that was patented in 1968.
• In the European Union, stiripentol is indicated for use in conjunction with clobazam and valproate as adjunctive therapy of refractory generalized tonic-clonic seizures in people with severe myoclonic epilepsy in infancy (SMEI, Dravet's syndrome) whose seizures are not adequately controlled with clobazam and valproate.
• Seizures in Dravet syndrome can be difficult to manage but may be reduced by anticonvulsant medications such as clobazam, stiripentol, topiramate and valproate.
• Some treatments might show efficacy in a relevant proportion of patients, such as valproic acid, vigabatrin, clobazam or sodium channel blockers, as well as a ketogenic diet.
• Arfendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring, and so is most closely related to other 1,5-benzodiazepines such as clobazam.
• Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.
• It was first approved by the FDA under the same brand name in October 2012, and then in June 2015, for the same uses as those in the European Union; it was one of four new drugs for epilepsy approved between 2010 and 2016, along with clobazam (Onfi), retigabine (Potiga), and eslicarbazepine acetate (Aptiom).
• He contributed to Phase I/II studies of a variety of drugs (such as the psychotropic agents nomifensine, etifoxine, clobazam and loprazolam, and the biologic drugs streptokinase and haemaccel) at the Pharmacologic and Medical Department of Hoechst AG, Behringwerke in Germany.
• Seizures persist despite treatment with medication, however several medications including valproic acid, stiripentol, clobazam, fenfluramine and pharmaceutical grade cannabidiol are often helpful to decrease seizure burden.
• Commonly used ASMs include valproic acid, clobazam, vigabatrin, felbamate, steroids, and lamotrigine for seizures, although comprehensive data are limited for the efficacy and safety of ASMs in CDD; medications for infantile spasms include ACTH, prednisolone, and vigabatrin.
• Clobazam, eslicarbazepine, felbamate, lamotrigine, rufinamide and topiramate are examples of weak enzyme-inducing ASMs.
• SPATCCM is an incurable genetic disease, however patients are often treated with anti-epileptics including vigabatrin, topiramate or clobazam, to reduce associated seizures.

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