Definition, Meaning & Anagrams | English word COMT

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Definitions of COMT

1. (biochemistry) Initialism of catechol-O-methyltransferase.

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Examples of Using COMT in a Sentence

• Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.
• They are also common substituents in O-methylated flavonoids, whose formation is catalyzed by O-methyltransferases that act on phenols, such as catechol-O-methyl transferase (COMT).
• Enzymes that regulate the biosynthesis or metabolism of dopamine such as aromatic L-amino acid decarboxylase or DOPA decarboxylase, monoamine oxidase (MAO), and catechol O-methyl transferase (COMT) may be referred to as dopaminergic as well.
• Opicapone (BIA 9-1067), Bial's second pharmaceutical, is a COMT inhibitor for the treatment of Parkinson disease, It is under review by the European Medicines Agency (EMA).
• COMT eliminates biologically active catechols present in catecholamines (dopamine, norepinephrine, and epinephrine) and their hydroxylated metabolites.
• Both degradations involve the enzymes monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT), albeit in reverse order: MAO catalyzes dopamine to DOPAC, and COMT catalyzes DOPAC to HVA; whereas COMT catalyzes dopamine to 3-MT and MAO catalyzes 3-MT to HVA.
• Tolcapone appears to be peripherally selective, but can still cross into the brain in significant amounts and has been found to inhibit COMT centrally as well.
• Some tax resisters advocate legal recognition of a right to COMT, while others conscientiously resist taxes without concern for whether their stand has legal approval.
• Tolcapone inhibits the catechol-O-methyltransferase (COMT) enzyme, which degrades dopamine and levadopa, thereby prolonging the therapeutic effects of levodopa.
• Several features of the structure like this folding lip suggest that PNMT is a recent adaptation to the catecholamine synthesizing enzyme family, evolving later than COMT, but before other methyltransferases like GNMT.
• Entacapone and opicapone are peripherally selective inhibitors, unable to cross the blood–brain barrier (BBB), and hence do not inhibit COMT in the brain.
• Like epinephrine, adrenalone is metabolised by catechol-O-methyl transferase (COMT), yielding 3O-methyladrenalone, which in turn is N-demethylized by monoamine oxidase (MAO).
• Other metabolic pathways of dopamine metabolism include methylation by catechol O-methyltransferase (COMT) into 3-methoxytyramine and β-hydroxylation by dopamine β-hydroxylase (DBH) into norepinephrine.
• C22orf25 is in close proximity to DGCR8 as well as other genes known to play a part in DiGeorge Syndrome such as armadillo repeat gene deleted in Velocardiofacial syndrome (ARVCF), Cathechol-O-methyltransferase (COMT) and T-box 1 (TBX1).
• Nitecapone (INN; OR-462) is a drug which acts as a selective inhibitor of the enzyme catechol O-methyl transferase (COMT).
• Louisville Bd Educ, 1968 & 1972; Housing Com Louisville C C, 1985; Housing Task Force Louisville C C; Mayor's Housing Task Force under Mayor Frank Burke; Nat An Community Develop; bd dir, State KY Housing Corp; Coun, Nat Cr Housing Mgt Wash; adv comt, Non-Profit Housing Ctr; vice chmn, Jefferson Co Bd Edu; Dist Lines Subcom Charter Com Merger Louisville & Jefferson Co Schs; former mem bd, Louisville NAACP, W Louisville Optimist Club; past chmn, Shawnee Dist Boy Scouts Am; pres, Just Men's Civic & Social Club; exec secy, Louisville & Jefferson Co Community Action Com; vice Chmn bd mgrs, YMCA; chmn, Fifth Region KY Sch Bd Asn; Gov's Adv Con Educ; Fed Rels Network Nat Sch Bd Asn; dir, chair, Nat Caucus Black Sch, Ky City; Asn Realtors.
• The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in extrahepatic tissues, and are metabolized by catechol O-methyltransferase (COMT) into methoxylated estrogens such as 2-methoxyestradiol and 4-methoxyestrone as well as by conjugation via other phase II enzymes.
• The COMT inhibitor opicapone is used as an additive to a combination of levodopa and a DOPA decarboxylase inhibitor to treat patients with Parkinson's disease experiencing end-of-dose motor fluctuations, if they cannot be stabilised with this drug combination.
• COMT, a blood-borne enzyme, mediates the most common form of 2- or 4-hydroxyestradiol inactivation, in addition to glucuronidation and sulfation.
• Antwoort op verscheyden obiectien ofte tegenworpingen betreffende den artyckel van die eewige predestinatie, ofte voorschickinghe Gods, waer mede bewesen wart, dat niemant door Gods voorordeninghe tot desselvighen haet ofte tot den doot ende verdoemenisse comt, maer alleene door zijn selfs boosheyt ofte sonde, uitg.

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