Anagrammi & Informazioni su | Parola Inglese PARP

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Esempi di utilizzo di PARP in una frase

• Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes.
• Chlorophyllin has been validated to exhibit ameliorative effects against food additive induced genotoxicity (elevating the expression of DNA repair proteins p53 and PARP) and mitochondrial dysfunction and may be used as a therapeutic tool for the management of diseases like diabetes and cancer.
• mTNBC +BRCA: patients previously treated with chemotherapy in the neoadjuvant, adjuvant, or metastatic disease should be offered PARP inhibitor rather than chemotherapy.
• PARP activity (which is mainly due to PARP1) measured in the permeabilized mononuclear leukocyte blood cells of thirteen mammalian species (rat, guinea pig, rabbit, marmoset, sheep, pig, cattle, pigmy chimpanzee, horse, donkey, gorilla elephant and man) correlates with maximum lifespan of the species.
• Lymphoblastoid cell lines established from blood samples of humans who lived past 100 years (centenarians) have significantly higher activity of the DNA repair protein Poly (ADP-ribose) polymerase (PARP) than cell lines from younger individuals (20 to 70 years old).
• When combined with treatment of PARP (poly (ADP-ribose) polymerase) inhibitor (known as PARPi), these cells showed an even greater reduction in telomere length, arresting tumor cell proliferation both in vitro and in vivo via mouse models grafted with various HNSCC cell lines.
• In January 2018, olaparib was approved in the United States for the treatment of patients with certain types of breast cancer that have spread (metastasized) and whose tumors have a specific inherited (germline) genetic mutation, making it the first drug in its class (PARP inhibitor) approved to treat breast cancer, and it is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a “BRCA” gene mutation.
• Iniparib (BSI 201, developed by Sanofi) was determined in 2012 not to be a true PARP inhibitor and failed trial for triple negative breast cancer.
• In the same study administration of proadifen was demonstrated to produce time- and dose-dependent phosphatidylserine externalization, caspase-3 activation and PARP cleavage.
• So it's bumped along by the kind of plastic electronic parp you could snap up on Freecycle, echoing Gorillaz' "Doncamatic" in its cheap-as-chips bop, and wigging out to a 'chorus' of frenzied fuzz-bass that'd slot nicely into the more annoying nooks of Think Tank.
• Procyclins also known as procyclic acidic repetitive proteins or PARP are proteins developed in the surface coating of Trypanosoma brucei parasites while in their tsetse fly vector.
• These compounds do not trigger apoptosis and therefore do not cause chromatin margination or poly (ADP-ribose) polymerase (PARP) cleavage.
• As a member of NATO Partnership for Peace (PfP) and NATO Euro-Atlantic Partnership Council (EAPC), Ireland participates in the PfP Planning and Review Process (PARP), and as part of this process the Defence Forces have adopted Partnership Goals aimed at assisting Ireland to meet its United Nations and European Union commitments in the areas of Counter Improvised Explosive Devices (C-IED), and improving the Irish military's interoperability with other professional military forces in this area.
• Current clinical trials are evaluating anti-PD-1 and PD-L1 drugs in combination with other immunotherapy drugs blocking LAG3, B7-H3, KIR, OX40, PARP, CD27, and ICOS.
• A 2012 study in a cell line found that PARP inhibitors exhibit cytotoxic effects not based solely on their enzymatic inhibition of PARP, but by their trapping of PARP on damaged DNA, and the strength of this trapping activity was ordered niraparib >> olaparib >> veliparib.
• Because NADH is a cofactor for processes inside mitochondria, for sirtuins and PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent.
• They discovered that poly (ADP-ribose) (PAR) polymer, the byproduct of PARP activation, is a novel cell death signaling molecule that plays a critical role in neuronal injury through apoptosis inducing factor and activation of nuclease activity of macrophage migration inhibitory factor in a cell death pathway designated parthanatos.
• 7-Methylguanine is a natural inhibitor of poly (ADP-ribose) polymerase (PARP) and tRNA guanine transglycosylase (TGT) - and thus may exert anticancer activity.
• She is the principal investigator of ongoing phase 1 and 2 studies, with a PARP inhibitor (olaparib) in combination with carboplatin or cediranib, and other biologic agents.
• In particular, these studies demonstrated that peroxynitrite induces breaks in the strands of the genetic material, DNA, which activate poly (ADP-ribose) polymerase (PARP), a mammalian nuclear and mitochondrial enzyme, which, in turn, induces cell necrosis, promotes inflammation and impairs vascular reactivity in various diseases.
• It contains niraparib, a poly (ADP-ribose) polymerase (PARP) inhibitor (antineoplastic agent), and abiraterone acetate, a CYP17 inhibitor (hormone antagonist).

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