Anagrams & Informasjon om | Engelsk ordet CALPAIN

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Eksempler på bruk av CALPAIN i en setning

• In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytoskeleton.
• The calpain proteolytic system includes the calpain proteases, the small regulatory subunit CAPNS1, also known as CAPN4, and the endogenous calpain-specific inhibitor, calpastatin.
• Excess calcium entry overexcites cells and causes the generation of harmful chemicals like free radicals, reactive oxygen species and calcium-dependent enzymes such as calpain, endonucleases, ATPases, and phospholipases in a process called excitotoxicity.
• Cysteine endopeptidases are a group of enzymes that also include the more distantly related papain derived from papaya latex, bromelase (bromelain) extracted from pineapple stem, calpain, caspases, cathepsin B, and chymopapain.
• Calpain cleavage of cytoskeletal protein filamin which is increased in prostate cancer could induce the nuclear translocation of FHL2, and this subsequently increase AR coactivation.
• This includes a binding site for SA1 or SA2, recognition motifs for separase, caspase, and calpain to cleave, as well as a region that is competitively bound by PDS5A, PDS5B or NIPBL.
• It has since been shown to inhibit many cysteine peptidases such as papain, cathepsin B, cathepsin L, calpain and staphopain.
• Talin is also post-translationally modified via calpain 2-mediated cleavage, which may target it for ubiquitin-proteasome-mediated degradation and turnover of associated cell adhesion structures.
• He is credited with key descriptions in the field of cardiomyopathies with desmin overload, severe autosomal recessive myopathies in children with adhaline deficiency (gamma - sarcoglycan), congenital muscular dystrophies of toddlers with merosin deficiency, and limb-girdle muscular dystrophies in juveniles, rediscovered in a genetic isolate from Reunion Island, with Calpain 3 deficiency, dystrophies subsequently found throughout the world.

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