Definition & Meaning | English word HOLIN
HOLIN
Definitions of HOLIN
- (biology) Any of a diverse group of small proteins produced by dsDNA bacteriophages in order to trigger and control the degradation of the host's cell wall at the end of the lytic cycle.
Number of letters
5
Is palindrome
No
Examples of Using HOLIN in a Sentence
- Mature virons are released by lysis, which, in the case of PRD1, is achieved with the aid of virus-encoded lysis machinery consisting of four proteins: P15 (endolysin), P35 (holin), P36 and P37 (homologues of the Rz/Rz1 proteins of phage lambda).
- As in holin superfamily I, proteins in these families generally exhibit of 2 transmembrane spanners (TMSs).
- Expression of holin S at a precisely scheduled time after phage infection terminates respiration and allows release of a muralytic enzyme, endolysin, that hydrolyzes the cell wall.
- Although the endolysin of phage T4 encoded by the e gene (Lysozyme E) was identified in 1961, the holin (product of gene t and called T-holin) was not characterized until 2001.
- CidA, a 131 aa protein with 4 putative TMSs, is believed to be the holin which exports the autolysin CidB, while LrgA may be an anti-holin, a protein that binds and inhibits holin activity.
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